Transforming growth factor- 1 increases airway wound repair via MMP-2 upregulation: a new pathway for epithelial wound repair?
نویسندگان
چکیده
E. Lechapt-Zalcman, V. Prulière-Escabasse, D. Advenier, S. Galiacy, C. Charrière-Bertrand, A. Coste, A. Harf, M.-P. d’Ortho, and E. Escudier Institut National de la Santé et de la Recherche Médicale, Unité U651, Faculté de Médecine, Université Paris XII, Créteil; Service d’Anatomie Pathologique, Centre Hospitalier Universitaire de Caen, Caen; Service d’ORL et de Chirurgie Cervico-Faciale, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris et Hôpital Intercommunal, Créteil; Service de Physiologie-Explorations Fonctionnelles, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; and Département de génétique, cytogénétique et embryologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France
منابع مشابه
Transforming growth factor-beta1 increases airway wound repair via MMP-2 upregulation: a new pathway for epithelial wound repair?
In vivo, transforming growth factor (TGF)-beta1 and matrix metalloproteinases (MMPs) present at the site of airway injury are thought to contribute to epithelial wound repair. As TGF-beta1 can modulate MMP expression and MMPs play an important role in wound repair, we hypothesized that TGF-beta1 may enhance airway epithelial repair via MMPs secreted by epithelial cells. We evaluated the in vitr...
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